Combined monophasic oral hormonal contraceptive drug. When taken orally, it inhibits the pituitary secretion of gonadotropic hormones. The contraceptive effect is associated with several mechanisms. As a progestogen component (progestin), it contains a derivative of 19-nortestosterone - levonorgestrel, which is superior in activity to the hormone of the corpus luteum progesterone (and the synthetic analogue of the latter - pregnin), acts at the receptor level without prior metabolic transformations. The estrogenic component is ethinylestradiol.
Under the influence of levonorgestrel, a blockade of the release of LH and FSH from the hypothalamus occurs, inhibition of the secretion of gonadotropic hormones by the pituitary gland, which leads to inhibition of the maturation and release of an egg ready for fertilization (ovulation). The contraceptive effect is enhanced by ethinyl estradiol. Maintains high viscosity of cervical mucus (makes it difficult for spermatozoa to enter the uterine cavity). Along with the contraceptive effect, when taken regularly, it normalizes the menstrual cycle and helps prevent the development of a number of gynecological diseases, incl. tumor nature.
Pharmacokinetics
Ethinylestradiol
Ethinylestradiol is rapidly and almost completely absorbed from the intestine. Ethinylestradiol undergoes a "first pass" effect through the liver, T max is 1.5 hours, T 1/2 is about 26 hours.
When administered orally, ethinylestradiol is excreted from the blood plasma within 12 hours, T 1/2 is 5.8 hours.
Ethinylestradiol is metabolized in the liver and intestines. Ethinyl estradiol metabolites, water-soluble sulfate or glucuronide conjugates, enter the intestine with bile, where they are disintegrated by intestinal bacteria.
Metabolized in the liver, T 1/2 is 2-7 hours.
Ethinylestradiol is excreted by the kidneys (40%) and through the intestines (60%).
It is allocated with breast milk.
Levonorgestrel
After oral administration, levonorgestrel is rapidly absorbed (less than 4 hours). Levonorgestrel does not undergo a "first pass" effect through the liver. With the combined use of levonorgestrel with ethinyl estradiol, there is a relationship between dose and maximum plasma concentration. T max (time to reach maximum concentration) of levonorgestrel is 2 hours, T 1/2 - 8-30 hours (average 16 hours). Most of levonorgestrel binds in the blood to albumin and SHBG (sex hormone-binding globulin). Metabolized in the liver.
Levonorgestrel is excreted by the kidneys (60%) and through the intestines (40%).
It is allocated with breast milk.
Release form
White film-coated tablets, round, biconvex.
Excipients: colloidal silicon dioxide - 0.275 mg, magnesium stearate - 0.55 mg, talc - 1.1 mg, corn starch - 19.895 mg, lactose monohydrate - 33 mg.
Shell composition: sucrose - 22.459 mg, talc - 6.826 mg, calcium carbonate - 3.006 mg, titanium dioxide - 1.706 mg, copovidone - 0.592 mg, macrogol 6000 - 0.148 mg, colloidal silicon dioxide - 0.146 mg, povidone - 0.088 mg, carmellose sodium - 0.029 mg.
21 pcs. - blisters (1) - packs of cardboard.
21 pcs. - blisters (3) - packs of cardboard.
Dosage
The drug is taken orally, without chewing and with a small amount of liquid.
If during the previous menstrual cycle hormonal contraception was not carried out, then Rigevidon ® for the purpose of contraception is prescribed from the 1st day of menstruation daily, 1 tablet for 21 days. This is followed by a 7-day break, during which menstrual-like bleeding occurs. The next 21-day cycle of taking tablets from a new package containing 21 tablets must be started the day after the 7-day break, i.e. on the 8th day, even if the bleeding has not stopped. Thus, the start of taking the drug from each new package falls on the same day of the week.
When switching to taking Rigevidon from another oral contraceptive, a similar scheme is used. The drug is taken for as long as there is a need for contraception.
After childbirth, the drug can be prescribed only to women who are not breastfeeding; you should start taking a contraceptive no earlier than the 1st day of menstruation. During lactation, the use of the drug is contraindicated.
The missed pill should be taken within the next 12 hours. If 36 hours have passed since the last pill was taken, then contraception is unreliable. To avoid intermenstrual spotting the drug should be continued from the already started package, with the exception of the missed tablet(s). In cases of missed tablets, it is recommended to additionally use another, non-hormonal method of contraception (for example, a barrier).
For therapeutic purposes, the doctor sets the dose of Rigevidon and the scheme of application in each case individually.
Overdose
Cases of development of toxic effects due to overdose are unknown.Interaction
Barbiturates, some antiepileptic drugs (carbamazepine, phenytoin), sulfonamides, pyrazolone derivatives can increase the metabolism of the steroid hormones that make up the drug.
A decrease in contraceptive efficacy can also be observed when administered simultaneously with certain antimicrobial agents (including ampicillin, rifampicin, chloramphenicol, neomycin, polymyxin B, sulfonamides, tetracyclines), which is associated with a change in the intestinal microflora.
With simultaneous use with anticoagulants, coumarin or indandione derivatives, an additional determination of the prothrombin index and a change in the dose of the anticoagulant may be required.
When using tricyclic antidepressants, maprotiline, beta-blockers, their bioavailability and toxicity may increase.
When using oral hypoglycemic drugs and insulin, it may be necessary to change their dose.
When combined with bromocriptine, its effectiveness is reduced.
When combined with drugs with a potential hepatotoxic effect, for example, with the drug dantrolene, an increase in hepatotoxicity is observed, especially in women over 35 years of age.
Side effects
The drug is usually well tolerated.
Possible side effects transient nature, spontaneously passing: nausea, vomiting, headache, engorgement of the mammary glands, changes in body weight and libido, mood changes, acyclic spotting; in some cases - swelling of the eyelids, conjunctivitis, blurred vision, discomfort when wearing contact lenses (these phenomena are temporary and disappear after cancellation without prescribing any therapy).
With prolonged use, chloasma, hearing loss, generalized itching, jaundice, cramps of the calf muscles, and an increase in the frequency of epileptic seizures can very rarely occur.
Rarely observed hypertriglyceridemia, hyperglycemia, reduced glucose tolerance, increased blood pressure, thrombosis and venous thromboembolism, jaundice, skin rashes, changes in the nature of vaginal secretion, candidiasis, fatigue, diarrhea.
Indications
- oral contraception;
- functional disorders of the menstrual cycle (including dysmenorrhea without an organic cause, dysfunctional metrorrhagia);
- premenstrual tension syndrome.
Contraindications
- severe liver disease;
- congenital hyperbilirubinemia (Gilbert's syndrome, Dubin-Johnson syndrome, Rotor's syndrome);
- cholecystitis;
- the presence or indication of a history of severe cardiovascular and cerebrovascular diseases;
- thromboembolism and predisposition to them;
- malignant tumors (primarily breast or endometrial cancer);
- liver tumors;
- familial forms of hyperlipidemia;
- severe forms of arterial hypertension;
- endocrine diseases (including severe forms diabetes);
- sickle cell anemia;
- chronic hemolytic anemia;
- vaginal bleeding of unknown etiology;
- cystic skid;
- migraine;
- otosclerosis;
- idiopathic jaundice of pregnant women in history;
- severe itching during pregnancy;
- herpes of pregnant women;
- age over 40;
- pregnancy;
- lactation period (breastfeeding);
- hypersensitivity to the components of the drug.
The drug should be used with caution in diseases of the liver and gallbladder, epilepsy, depression, ulcerative colitis, uterine myoma, mastopathy, tuberculosis, kidney disease, diabetes mellitus, diseases of the cardiovascular system, arterial hypertension, impaired renal function, varicose veins, phlebitis, otosclerosis, multiple sclerosis, chorea minor, intermittent porphyria, latent tetany, bronchial asthma, in adolescence (without regular ovulatory cycles).
Application features
Use during pregnancy and lactation
The drug is contraindicated during pregnancy and lactation (breastfeeding).Application for violations of liver function
Use is contraindicated in severe liver diseases (including congenital hyperbilirubinemia - Gilbert, Dubin-Johnson and Rotor syndromes; liver tumors).Application for violations of kidney function
Caution is required if it is necessary to prescribe the drug to patients with impaired renal function.Use in elderly patients
Contraindicated in people over 40 years of age.special instructions
Before starting the use of hormonal contraception and subsequently every 6 months, a general medical and gynecological examination is recommended, including a cytological analysis of a smear from the cervix, an assessment of the condition of the mammary glands, determination of blood glucose, cholesterol and other indicators of liver function, blood pressure control, urinalysis.
The appointment of Rigevidon for women with thromboembolic diseases at a young age and an increase in blood coagulation in a family history is not recommended.
The use of oral contraception is allowed no earlier than 6 months after viral hepatitis, subject to the normalization of liver function.
With the appearance of sharp pains in the upper abdomen, hepatomegaly and signs of intra-abdominal bleeding, a liver tumor may be suspected. If necessary, the drug should be discontinued.
If there is a violation of liver function while taking Rigevidon, a consultation with a therapist is necessary.
With the appearance of acyclic (intermenstrual) bleeding, Rigevidon should be continued, because. in most cases, these bleedings stop spontaneously. If acyclic (intermenstrual) bleeding does not disappear or recurs, a medical examination should be carried out to rule out organic pathology of the reproductive system.
In case of vomiting or diarrhea, the drug should be continued using another, non-hormonal method of contraception.
Women who smoke and take hormonal contraceptives have an increased risk of developing cardiovascular diseases with serious consequences (myocardial infarction, stroke). The risk increases with age and with the number of cigarettes smoked (especially in women over 35).
The drug should be discontinued in the following cases:
- when migraine-like headache appears for the first time or increases;
- with the appearance of an unusually severe headache;
- with the appearance of early signs of phlebitis or phlebothrombosis (unaccustomed pain or swelling of the veins in the legs);
- in the event of jaundice or hepatitis without jaundice;
- with cerebrovascular disorders;
- with the appearance of stabbing pains of unclear etiology when breathing or coughing, pain and a feeling of tightness in the chest;
- with acute deterioration of visual acuity;
- with suspicion of thrombosis or heart attack;
- with a sharp increase in blood pressure;
- in case of generalized itching;
- with an increase in epileptic seizures;
- 3 months before the planned pregnancy;
- approximately 6 weeks before the planned surgical intervention;
- with prolonged immobilization;
- during the onset of pregnancy.
Influence on the ability to drive vehicles and control mechanisms
Taking the drug does not affect the ability to drive vehicles and to control other mechanisms, work with which is associated with an increased risk of injury.
I describe my experience, that is, the information is subjective. However, on the Internet there are a lot of reviews about oral contraceptives with a negative connotation.
I was prescribed the drug Rigevidon for medicinal purposes, no one recommended hormone tests before that. To complaints about the side effects of Rigevidon, the doctor said to be patient, that this is not critical.
But 3 months of taking the pills turned out to be quite difficult for me.
Side effects
- severe pain in the vagina;
- persistent bleeding for 2 months;
- pain in the liver appeared after 2.5 months and before the end of the drug, it intensified so much that I woke up in a dream while moving (a common side effect of Rigevidon and other OKs);
- nausea, to the point of vomiting, lasted about a week every month;
- deterioration of vision was noted after 1.5 months of taking Rigevidon;
- pain in the area thyroid gland, feeling of suffocation, heaviness in the neck;
- pain in the heart of a periodic nature occurred at least 20 times in 3 months, previously it was noted only when taking the hormonal herb Red Brush (I had to drink Corvalol).
The expected result is the cleansing of the ovaries from small cysts in the diagnosis of "polycystic", one large cyst, as well as the elimination of a rash on the face. The cycle was perfect, 28 days.
I want to note that some side effects did not affect me personally, for example, from the reviews of women, Rigevidon led to weight gain, I did not notice this.
What do we have after using Rigevidon for 3 months
It turns out that the body recovered almost a year after the abolition of a 3-month course contraceptives. Perhaps some side effects, such as nausea, were due to the fact that this drug was not suitable for me, since we did not do hormone tests. I want to advise you to preferably do tests for hormones, they can be used to more accurately determine which drug is best suited for treatment. 
I also advise you to take milk thistle meal in parallel, 1-2 teaspoons a day, washed down with water to support the liver, since hormones strongly affect it. Regarding the thyroid gland: smear the body with iodine, eat Walnut, sea kale or take iodomarin.
I noted for myself that I would no longer want to drink hormones, since there are too many side effects from birth control pills, and I also noticed a difficult and lengthy recovery of the body after them.
Moreover, the effect is really short, and I’m not ready for lifelong use of OK, and I don’t see the point, especially since the cycle is regular and stable. Be healthy! I wish you to learn only from the mistakes of others, so as not to experience trouble.
Application instruction to Rigevidon
Registration number:
P N012676/02Tradename: RIGEVIDON ®
International non-proprietary name or grouping name: Ethinylestradiol + Levonorgestrel
Dosage form:
coated tabletsCOMPOSITION
Active substances:
Ethinylestradiol: 0.03 mg
Levonorgestrel; 0.15 mg
Excipients:
- in the tablet core:
colloidal silicon dioxide, magnesium stearate, talc, corn starch, lactose monohydrate;
- in a tablet shell:
sucrose, talc, calcium carbonate, titanium dioxide, copovidone, macrogol 6000, colloidal silicon dioxide, povidone, carmellose sodium.
Description
White, round, biconvex film-coated tablets.
Pharmacotherapeutic group:
contraceptive (estrogen + gestagen)ATC code: G03AA07.
PHARMACOLOGICAL PROPERTIES
Pharmacodynamics
Rigevidon is an oral monophasic combined estrogen-progestin contraceptive drug.
When taken orally, it inhibits the pituitary secretion of gonadotropic hormones.
The contraceptive effect is associated with several mechanisms. As a progestogen component (progestin), it contains a derivative of 19-nortestosterone - levonorgestrel, which is superior in activity to the hormone of the corpus luteum progesterone (and the synthetic analogue of the latter - pregnin), acts at the receptor level without prior metabolic transformations. The estrogenic component is ethinylestradiol. Under the influence of levonorgestrel, a blockade of the release of releasing hormones (LH and FSH) of the hypothalamus occurs, inhibition of the secretion of gonadotropic hormones by the pituitary gland, which leads to inhibition of the maturation and release of an egg ready for fertilization (ovulation). The contraceptive effect is enhanced by ethinyl estradiol. Maintains high viscosity of cervical mucus (makes it difficult for spermatozoa to enter the uterine cavity). Along with the contraceptive effect, when taken regularly, it normalizes the menstrual cycle and helps prevent the development of a number of gynecological diseases, incl. tumor nature.
Pharmacokinetics
Levonorgestrel is rapidly absorbed (less than 4 hours). Levonorgestrel does not have a first pass effect through the liver. With the combined use of levonorgestrel with ethinyl estradiol, there is a relationship between dose and maximum plasma concentration. TC max (time to reach maximum concentration) of levonorgestrel is 2 hours, T 1/2 (half-life) - 8-30 hours. (average 16 hours). Most of levonorgestrel binds in the blood to albumin and SHBG (Sex Hormone Binding Globulin).
Ethinylestradiol is rapidly and almost completely absorbed from the intestine. Ethinyl estradiol is characterized by the effect of the primary passage through the liver, TC max is 1.5 hours, the half-life is about 26 hours.
When administered orally, ethinylestradiol is excreted from the blood plasma within 12 hours, the elimination half-life is 5.8 hours.
The metabolism of ethinylestradiol is carried out in the liver and intestines. Ethinyl estradiol metabolites are water-soluble products of sulfate or glucuronide conjugation, enter the intestine with bile, where they are disintegrated by intestinal bacteria.
Both components (levonorgestrel and ethinylestradiol) are excreted in breast milk. Active substances are metabolized in the liver, T 1/2 is 2-7 hours.
excretion of levonorgestrel is carried out by the kidneys (60%) and through the intestines (40%); ethinylestradiol - by the kidneys (40%) and through the intestines (60%).
INDICATIONS FOR USE
Oral contraception, functional menstrual disorders (including dysmenorrhea without an organic cause, dysfunctional metrorrhagia, premenstrual syndrome).
CONTRAINDICATIONS
Hypersensitivity to the components of the drug, pregnancy, lactation, severe liver disease, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), cholecystitis, the presence or history of severe cardiovascular and cerebrovascular changes, thromboembolism and predisposition to them , liver tumors, malignant tumors, especially breast or endometrial cancer; familial forms of hyperlipidemia, severe forms of arterial hypertension, severe forms of diabetes mellitus and other diseases of the endocrine glands, sickle cell anemia, chronic hemolytic anemia, hydatidiform drift, age over 40 years, vaginal bleeding of unknown etiology, migraine, otosclerosis; history of idiopathic jaundice of pregnant women, severe pruritus of pregnant women, herpes of pregnant women.
CAREFULLY
Diseases of the liver and gallbladder, epilepsy, depression, ulcerative colitis, uterine fibroids, mastopathy, tuberculosis, kidney disease, teenage years(without regular ovulatory cycles).
In the presence of diabetes mellitus, diseases of the cardiovascular system, arterial hypertension, impaired renal function, varicose veins veins, phlebitis, otosclerosis, multiple sclerosis, epilepsy, chorea minor, intermittent porphyria, latent tetany, bronchial asthma prescribing the drug also requires caution.
PREGNANCY AND LACTATION
During pregnancy and lactation, the drug is contraindicated.
METHOD OF APPLICATION AND DOSES
Apply inside, without chewing and drinking a small amount of liquid.
If hormonal contraception was not performed during the previous menstrual cycle, contraception with Rigevidon is started from the first day of menstruation, taking 1 tablet daily for 21 days, at the same time of day.
This is followed by a 7-day break, during which menstrual-like bleeding occurs. The next 21-day tablet cycle from a new package containing 21 tablets must be started the day after the 7-day break, i.e. on the eighth day, even if the bleeding has not stopped. Thus, the start of taking the drug from each new package falls on the same day of the week.
When switching to taking Rigevidon from another oral contraceptive, a similar scheme is used. The drug is taken for as long as there is a need for contraception.
After an abortion, it is recommended to start taking the drug on the day of the abortion or the day after the operation.
After childbirth, the drug can be prescribed only to women who are not breastfeeding; you should start taking contraceptives no earlier than the first day of menstruation. During lactation, the use of the drug is contraindicated.
missed pills; the missed tablet should be taken within the next 12 hours. If 36 hours have passed since the last pill, contraception is unreliable. In order to avoid intermenstrual bleeding, the drug should be continued from the already started package, with the exception of the missed tablet(s). In cases of skipping pills, it is recommended to additionally use another, non-hormonal method of contraception (eg, barrier).
For medicinal purposes; the dose of Rigevidon and the scheme of application are selected by the doctor in each case individually.
SIDE EFFECT
The drug is usually well tolerated.
Possible side effects of a transient nature, spontaneously passing: nausea, vomiting, headache, breast engorgement, changes in body weight and libido, mood changes, acyclic spotting, in some cases - swelling of the eyelids, conjunctivitis, blurred vision, discomfort when wearing contact lenses (these phenomena are temporary and disappear after discontinuation without prescribing any therapy).
With prolonged use, chloasma, hearing loss, generalized itching, jaundice, cramps of the calf muscles, and an increase in the frequency of epileptic seizures can very rarely occur. Rarely, hypertriglyceridemia, hyperglycemia, decreased glucose tolerance, increased blood pressure (BP), thrombosis and venous thromboembolism, jaundice, skin rashes, changes in the nature of vaginal secretion, vaginal candidiasis, increased fatigue, diarrhea are noted.
OVERDOSE
Cases of development of toxic effects due to overdose are unknown.
INTERACTION WITH OTHER DRUGS
Barbiturates, some antiepileptic drugs (carbamazepine, phenytoin), sulfonamides, pyrazolone derivatives can increase the metabolism of steroid hormones that make up the drug.
A decrease in contraceptive efficacy can also be observed when administered simultaneously with certain antimicrobial drugs (ampicillin, rifampicin, chloramphenicol, neomycin, polymyxin B, sulfonamides, tetracyclines), which is associated with a change in the microflora in the intestine.
When using anticoagulants, coumarin or indandione derivatives, it may be necessary to additionally determine the prothrombin index and change the dose of the anticoagulant.
When using tricyclic antidepressants, maprotiline, beta-blockers, their bioavailability and toxicity may increase.
When using oral hypoglycemic drugs and insulin, it may be necessary to change their dose.
When combined with bromocriptine, the effectiveness of bromocriptine is reduced.
When combined with drugs with a potential hepatotoxic effect, for example, with the drug dantrolene, an increase in hepatotoxicity is observed, especially in women over 35 years of age.
SPECIAL INSTRUCTIONS
Before starting contraception and, thereafter, every 6 months. a general medical and gynecological examination is recommended, including a cytological analysis of a smear from the cervix, an assessment of the condition of the mammary glands, determination of blood glucose, cholesterol and other indicators of liver function, blood pressure control, urinalysis).
The appointment of Rigevidon to women with thromboembolic diseases at a young age and an increase in blood clotting in a family history is not recommended.
The use of oral contraception is allowed no earlier than 6 months after viral hepatitis, subject to the normalization of hepatic functions.
With the appearance of sharp pains in the upper abdomen, hepatomegaly and signs of intra-abdominal bleeding, a liver tumor may be suspected. If necessary, the drug should be discontinued.
In case of deterioration of hepatic functions while taking Rigevidon, a therapist's consultation is necessary.
With the appearance of acyclic (intermenstrual) bleeding, Rigevidon should be continued, since in most cases these bleedings stop spontaneously. If acyclic (intermenstrual) bleeding does not disappear or recurs, a medical examination should be carried out to rule out organic pathology of the reproductive system.
In case of vomiting or diarrhea, the drug should be continued, additionally using another, non-hormonal method of contraception.
Women who smoke and take hormonal contraceptives have an increased risk of developing vascular diseases with serious consequences (myocardial infarction, stroke). The risk increases with age and with the number of cigarettes smoked (especially in women over 35).
The drug should be discontinued in the following cases:
- when a migraine-like headache appears for the first time or increases, or an unusually severe headache appears;
- with the appearance of early signs of phlebitis or phlebothrombosis (unusual pain or swelling of the veins in the legs);
- in case of jaundice or hepatitis without jaundice;
- with cerebrovascular disorders;
- with the appearance of stabbing pains of unclear etiology when breathing or coughing, pain and a feeling of tightness in the chest;
- with acute deterioration of visual acuity;
- in case of suspected thrombosis or infarction;
- with a sharp increase in blood pressure;
- in case of generalized itching;
- with an increase in epileptic seizures;
- 3 months before the planned pregnancy, approximately 6 weeks before the planned surgical intervention, with prolonged immobilization.
- in the presence of pregnancy.
EFFECT OF THE DRUG ON THE ABILITY TO DRIVE A CAR AND OTHER MECHANISMS
Taking the drug does not affect the ability to drive a car and other mechanisms, work with which is associated with an increased risk of injury.
RELEASE FORM
Tablets;
21 tablets in a blister made of PVC / PVDC film and aluminum foil;
1 or 3 blisters in a cardboard box with instructions for use.
STORAGE CONDITIONS
At a temperature of 15-30 °C.
Keep the drug in a place inaccessible to children!
BEST BEFORE DATE
5 years. Do not use after the expiration date.
TERMS AND CONDITIONS OF DISCOUNT FROM PHARMACIES
On prescription.
MANUFACTURER
OJSC "Gedeon Richter",
1103 Budapest, st. Demrei, 19-21, Hungary.
Consumer claims should be sent to:
Moscow Representative Office of JSC "Gedeon Richter"
Regividon is the best solution!
Advantages: No side effects, reasonable price, compatibility with other drugs.
Cons: not found
After the birth of two wonderful toddlers, my husband and I thought about contraception. After consulting with my gynecologist, I decided to opt for Rigevidon. It is convenient that you can swallow them even without drinking water. The doctor immediately warned that you should take a pill every day at the same time and not skip doses in any case. Most of all, I was probably afraid that with taking pills and excess weight will come, but nothing like that happens to this day. The only thing was that at the very beginning of the reception there was a slight nausea, but then it passed. Menstruation comes without delay. I will say that I have been using Rigevidon for more than five years, occasionally taking small breaks to rest the body, and during all this time there were no problems. The drug works great.
No effect is worth the health spent, avoid
Benefits: Effective contraception, price
Disadvantages: Huge harm to health and strong side effects
She refused hormonal contraceptives, because she drank Rigevidon and found out for herself what harm they cause. Hormonal contraceptives are guaranteed to be effective, which is why they were so popular, and now people understand how harmful they are. I used them for a while, and was happy - the pills really work, they are very inexpensive, besides. But over time, I realized that a lot of the problems that I had were caused by this particular drug. We start with the mood - a hysterical vixen, who is irritated by everything and always, yells, cries all the time and behaves inappropriately - here's my portrait after 2 months of taking Rigevidon. And by nature, I’m rather even a phlegmatic person, I don’t suffer from emotionality at all. The second is weight. A painful question, because in 3 months of use I did not add a couple of kilograms, but 9.2 kg !!! I went to the gym, rocked, to no avail, I usually lose weight easily, but here my legs and arms are thinner (the muscles go away), and the fat on my stomach is nowhere. This is due to progesterone, the amount of which increases greatly when taken. hormonal pills. The third is the pressure, which has increased from my usual 110 to 150! So it won't take long to become hypertensive. Then there was a lot of everything else, I won’t paint, briefly: frequent thrush, terrible chest pains, painful periods and PMS with terrible discomfort, acne all over my face, and the highlight of the program is jaundice, which I never had. How do I know that drug cause? Analyzes, banal tests for hormones and an intelligent gynecologist. Then all these problems had to be eliminated for a very long time, because girls - treat yourself carefully and do not use such filth.
Strong hormonal drug
Advantages: reasonable price
Disadvantages: side effects, weight gain, irritability appears
A few months ago, my sister was diagnosed with fibromyoma and, after a while, she began to increase in size. The doctor she went to after checking hormonal background and other tests, prescribed Rigevidon for some reason. The motivation was this: normalizes monthly cycle(which really went astray to her, there were blood smears), will be the prevention of unplanned pregnancies and will slow down the development of the fibromatous node. The drug itself is not bad, available in pharmacies, the price is reasonable. But, there is one significant downside. My sister and I saw each other after 2 months and I did not immediately recognize her. She gained 7 kg in 2 months! Then she said that her libido had weakened and she became nervous. As for fibroids, there was no noticeable result in 2 months. As a result, they refused Regividon, and my sister is taking another drug.
Rigevidon is produced in tablets, packaged in blisters of 21 pieces, 3 or 1 blisters per pack.
pharmachologic effect
Rigevidon tablets show contraceptive action.
Pharmacodynamics and pharmacokinetics
This oral monophasic combined estrogen-progestin contraceptive drug is able to have an inhibitory effect on the pituitary production of gonadotropic.
In this case, the contraceptive action is associated with several mechanisms. Progestogen component progestin includes a derivative of 19-nortestosterone known as levonorgestrel . This substance surpasses the corpus luteum hormone in its activity. or its synthetic equivalent pregnin , which has an effect at the receptor level, without being exposed.
The estrogenic component ethinyl estradiol leads to blockade of the release of releasing hormones of the hypothalamus, inhibition of the production of gonadotropic hormones by the pituitary gland. This slows down the maturation and release of the egg, ready for fertilization.
It has been established that ethinylestradiol enhances the contraceptive effect of the drug. The increased viscosity of the cervical mucus persists, which makes it difficult for sperm to penetrate.
Also, regular intake of the drug leads to the normalization of the menstrual cycle and prevents the development of certain gynecological diseases, such as tumors.
Inside the body, the drug is rapidly absorbed. The concentration of Rigevidon depends on the dosage of the drug and the duration of use. In this case, the maximum concentration is usually detected after 2 hours, excretion occurs on average in 16 hours. The drug is excreted unchanged by the intestines and kidneys.
Indications for use
- oral contraception;
- functional disorders of the menstrual cycle, for example, unspecified , dysfunctional metrorrhagia, .
Contraindications
Rigevidon contraceptive pills are not prescribed for:
- drug sensitivity;
- , ;
- serious illnesses liver;
- congenital hyperbilirubinemia;
- thromboembolism;
- tumor diseases;
- severe forms arterial hypertension;
- and other diseases of the endocrine glands;
- sickle cell anemia ;
- chronic hemolytic anemia;
- cystic skid;
- aged 40 years;
- otosclerosis.
Also, the drug is contraindicated for use with bleeding of various origins, idiopathic jaundice, and in pregnant women.
With caution, Rigevidon is prescribed to patients with diseases of the liver, kidneys and gallbladder, , ulcerative, mastopathy, , diseases of the cardiovascular system, arterial hypertension, impaired renal function, , phlebitis , otosclerosis and scattered . Also, caution is required when prescribing tablets to patients in adolescence.
Rigevidon during pregnancy and lactation
It has been established that during pregnancy and lactation, the use of this drug is contraindicated.
Side effects of Rigevidon
Usually this drug is well tolerated by patients, but sometimes side effects of Rigevidon occur, which develop transiently and disappear spontaneously. For example, nausea, vomiting, weight gain And change in libido , moods, manifestation of acyclic bleeding, conjunctivitis , vision problems and so on.
In rare cases long-term use the drug causes chloasma, hearing loss, jaundice, generalized, convulsions, the frequency of epileptic seizures, hypertriglyceridemia , hyperglycemia , increased pressure, thrombosis or venous thromboembolism, skin rashes, changes in vaginal secretion, high fatigue, and so on.
Tablets Rigevidon, instructions for use (Method and dosage)
When at the previous menstrual cycle hormonal contraception was not performed, then it should be started on the 1st day of menstruation. Then you need to take one tablet every day for 21 days, preferably at a certain time of the day.
After that, a break of 7 days is carried out, during which menstrual-like bleeding occurs. For the next 21 days, the tablets are taken from a new package, that is, already on the 8th day, regardless of whether the bleeding has stopped or not.
Switching to these birth control pills from another contraceptive is carried out according to the same scheme. You can take the drug as long as you need it.
The use of the drug for medicinal purposes requires individual selection of dosage and therapeutic regimen.
Overdose
There were no cases of overdose with Rigevidon.
Interaction
The combination with barbiturates, antiepileptic drugs, for example, and, as well as sulfonamides, pyrazolone derivatives, can lead to an increase in the metabolism that make up the drug.
The combined use of Rigevidon and some antimicrobial drugs can reduce the contraceptive effect: , Polymyxin B , sulfonamides and, since they change the composition of the intestine.
This drug may increase the bioavailability and toxicity of tricyclic antidepressants, beta-blockers and but , reduce efficiency .
Co-administration with hypoglycemic drugs and often requires a change in their dosage. When taken with the drug Dantrolene it is possible to increase its hepatotoxicity, mainly in women from the age of 35.
special instructions
Before you start taking contraceptive pills, and every six months when they are used, it is necessary to undergo a general medical and gynecological examination. It usually includes a cytological analysis, a study of the mammary glands, an assessment of blood glucose, liver function, pressure and urine composition.
Patients who have undergone viral hepatitis and their liver functions have normalized, the drug is prescribed no earlier than 6 months from the moment of recovery.
If there are sharp pains in the abdominal cavity, and signs intra-abdominal bleeding , this may indicate a tumor of the liver. If necessary, the drug is immediately canceled.
advent intermenstrual bleeding does not require the abolition of the contraceptive, as they usually stop on their own. When this does not happen, consultation with a gynecologist is necessary.
As you know, in women who smoke, when taking hormonal contraceptives vascular diseases can develop with severe consequences - myocardial infarction
There are many reviews when women took one of these drugs for a long time. This did not lead to the development of undesirable effects, such as a change in libido or weight gain. Moreover, immediately after the abolition of these contraceptives, pregnancy almost immediately occurred. Therefore, the selection of such drugs must be carried out taking into account individual characteristics after consultation with a gynecologist.
Alcohol and Rigevidon
There have been cases of a decrease in the effectiveness of this drug when alcohol is consumed in large quantities.
